Počet záznamov: 1
TDP-43 proteínopatie
SYS d057177 LBL 00000nx--j2200000---45-- 005 20240119200631.6 100 $a 20100101asloy0103----ba0 152 $b mesh 250 $a TDP-43 proteínopatie $x BL $x CF $x CI $x CL $x CN $x CO $x DG $x DH $x DI $x DT $x EC $x EH $x EM $x EN $x EP $x ET $x GE $x HI $x IM $x ME $x MI $x MO $x NU $x PA $x PC $x PP $x PS $x PX $x RH $x RT $x SU $x TH $x UR $x VE $x VI $8 slo 300 1-
$a 2010 $8 eng 330 1-
$a Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease. $8 eng 686 $a C10.574.950 686 $a C18.452.845.800 750 $a TDP-43 Proteinopathies $8 eng 801 -0
$a SK $b BA006 $c 20100316 801 -2
$a SK $b BA006 $c 20101109 980 $x M
Počet záznamov: 1