Počet záznamov: 1
progranulíny
SYS d000077153 LBL 00000nz--a2200181n--4500 005 20250606222637.2 008 190101|||anznnbabn-----------|-a|a------ 040 $b slo $a BA006 $d BA006 065 $a D06.472.699.682 065 $a D12.644.276.917 065 $a D12.776.467.917 065 $a D12.776.811.703 065 $a D23.529.917 066 $a 01 $c 03 150 $a progranulíny $x AA $x AD $x AE $x AG $x AI $x AN $x BI $x BL $x CF $x CH $x CL $x CS $x DF $x EC $x GE $x HI $x IM $x IP $x ME $x PD $x PH $x PK $x PO $x RE $x SD $x ST $x TO $x TU $x UR $2 slo 450 $w v $a akrogranín $2 slo 450 $w v $a Acrogranin $2 slo 450 $w v $a prekurzor granulínu $2 slo 450 $w v $a proteín prekurzorový granulínový $2 slo 450 $w v $a faktor rastový, odvodený od PC buniek $2 slo 450 $w v $a proepitelín $2 slo 450 $w v $a progranulín $2 slo 665 $a 2019 $2 eng 665 $a Intercellular Signaling Peptides and Proteins (1999-2018) $2 eng 680 9-
$i Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. $2 eng 750 -2
$a Progranulins $2 eng 980 $x M
Počet záznamov: 1