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botulotoxíny
SYS d001905 LBL 00000cz--a2200000n--4500 005 20250606213824.4 008 990101|||anznnbabn-----------|-a|a------ 040 $b slo $a DNLM $d BA006 $d BA006 065 $a D08.811.277.656.300.480.153 065 $a D08.811.277.656.675.374.153 065 $a D12.776.097.156 065 $a D23.946.123.179 066 $a 01 $c 03 150 $a botulotoxíny $x AD $x AE $x AG $x AI $x AN $x BI $x BL $x CF $x CH $x CL $x CS $x DE $x EC $x GE $x HI $x IM $x IP $x ME $x PD $x PH $x PK $x PO $x RE $x SD $x ST $x TO $x TU $x UL $x UR $2 slo 450 $w v $a Botulin $2 eng 450 $w v $a Botulinum Neurotoxin $2 eng 450 $w v $a Botulinum Neurotoxins $2 eng 450 $w v $a Clostridium botulinum Toxins $2 eng 450 $w v $a botulín $2 slo 450 $w v $a botulotoxíny klostrídiové $2 slo 450 $w v $a neurotoxín Botulinum $2 slo 450 $w v $a neurotoxíny botulínové $2 slo 450 $w v $a toxíny Clostridium botulinum $2 slo 550 $7 sllk_us_auth*d009498 $Y Neurotoxins $w P $a neurotoxíny 550 $7 sllk_us_auth*d065087 $Y Acetylcholine Release Inhibitors $w P $a inhibítory uvoľňovania acetylcholínu 550 $7 sllk_us_auth*d001906 $Y Botulism $w p $a botulizmus 550 $7 sllk_us_auth*d001906 $Y Botulism $w b $a botulizmus 550 $7 sllk_us_auth*d003014 $Y Clostridium botulinum $w b $a Clostridium botulinum 550 $7 sllk_us_auth*d018678 $Y Cholinergic Agents $w b $a látky cholínergické 665 $a 78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71) $2 eng 665 $a Clostridium Botulinum (1966-1968) $2 eng 665 $a Toxins (1966-1968) $2 eng 680 9-
$i Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS. $2 eng 680 $a /antag permitted but consider also BOTULINUM ANTITOXIN $2 eng 750 -2
$a Botulinum Toxins $2 eng 980 $x M
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