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etopozid

Č. záznamu	d005047
Dátum	06.06.2025
Typ	M - MESH
Tematický termín	etopozid
Iný termín	Angličtina (Pseudonym) Demethyl Epipodophyllotoxin Ethylidine Glucoside Slovenčina (Pseudonym) Etoposide Slovenčina (Pseudonym) demetylepipodofylotoxínetylidínglukozid
Pozri tiež	(Skutočné meno) antineoplastiká fytogénne (Skutočné meno) inhibítory topoizomerázy II
MDT	D02.455.426.559.847.638.960.675.250D04.615.638.960.675.250D09.408.348.275
Poznámka	A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

predmetové heslo

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