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myši knokautované
Č. záznamu d018345 Dátum 06.06.2025 Typ M - MESH Tematický termín myši knokautované Iný termín Angličtina (Pseudonym) Knockout Mice
Slovenčina (Pseudonym) myši knockout
Pozri tiež (Novšie záhlavie) inžinierstvo genetické
(Skutočné meno) techniky inaktivácie génu
(Novšie záhlavie) techniky inaktivácie génu
MDT B01.050.050.136.500.500B01.050.150.900.649.313.992.635.505.500.550.455B01.050.150.900.649.313.992.635.505.500.800.500 Poznámka Strains of mice in which certain GENES of their GENOMES have been disrupted, or knocked-out. To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes. 
predmetové heslo
Počet záznamov: 1