Počet záznamov: 1
antineoplastiká alkylačné
SYS d018906 LBL 00000cz--a2200000n--4500 005 20250606214814.7 008 950526|||anznnbabn-----------|-a|a------ 040 $b slo $a DNLM $d BA006 $d BA006 065 $a D27.505.519.124.035 065 $a D27.505.954.248.150 065 $a D27.888.569.035.035 066 $a 01 $c 03 150 $a antineoplastiká alkylačné $x AD $x AE $x AN $x BL $x CF $x CH $x CL $x CS $x EC $x HI $x IM $x IP $x ME $x PD $x PK $x PO $x RE $x SD $x ST $x TO $x TU $x UR $2 slo 450 $w v $a Alkylating Agents, Antineoplastic $2 eng 450 $w v $a látky antineoplastické alkylačné $2 slo 450 $w v $a látky protinádorové alkylačné $2 slo 665 $a 96 $2 eng 665 $a Alkylating Agents (1966-1995) $2 eng 665 $a Antineoplastic Agents (1966-1995) $2 eng 680 9-
$i A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) $2 eng 750 -2
$a Antineoplastic Agents, Alkylating $2 eng 980 $x M
Počet záznamov: 1