Počet záznamov: 1
progranulíny
SYS d000077153 LBL 00000nx^^^2200181-^^45^^ 005 20240119195325.1 100 $a 20190101asloy0103 ba0 152 $b mesh 250 $a progranulíny $x AA $x AD $x AE $x AG $x AI $x AN $x BI $x BL $x CF $x CH $x CL $x CS $x DF $x EC $x GE $x HI $x IM $x IP $x ME $x PD $x PH $x PK $x PO $x RE $x SD $x ST $x TO $x TU $x UR $8 slo 300 1-
$a 2019 $8 eng 300 1-
$a Intercellular Signaling Peptides and Proteins (1999-2018) $8 eng 330 1-
$a Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. $8 eng 450 $a akrogranín $5 e $8 slo 450 $a Acrogranin $5 e $8 slo 450 $a prekurzor granulínu $5 e $8 slo 450 $a proteín prekurzorový granulínový $5 e $8 slo 450 $a faktor rastový, odvodený od PC buniek $5 e $8 slo 450 $a proepitelín $5 e $8 slo 450 $a progranulín $5 e $8 slo 686 $a D06.472.699.682 686 $a D12.644.276.917 686 $a D12.776.467.917 686 $a D12.776.811.703 686 $a D23.529.917 750 $a Progranulins $8 eng 801 -0
$a SK $b BA006 $c 20190310 801 -2
$a SK $b BA006 $c 20190626 980 $x M
Počet záznamov: 1