Počet záznamov: 1
antineoplastiká alkylačné
SYS d018906 LBL 00000cx--j2200000---45-- 005 20240119200237.7 100 $a 19950526asloy0103----ba0 152 $b mesh 250 $a antineoplastiká alkylačné $x AD $x AE $x AN $x BL $x CF $x CH $x CL $x CS $x EC $x HI $x IM $x IP $x ME $x PD $x PK $x PO $x RE $x SD $x ST $x TO $x TU $x UR $8 slo 300 1-
$a 96 $8 eng 300 1-
$a Alkylating Agents (1966-1995) $8 eng 300 1-
$a Antineoplastic Agents (1966-1995) $8 eng 330 1-
$a A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) $8 eng 450 $a Alkylating Agents, Antineoplastic $5 e $8 eng 450 $a látky antineoplastické alkylačné $5 e $8 slo 450 $a látky protinádorové alkylačné $5 e $8 slo 686 $a D27.505.519.124.035 686 $a D27.505.954.248.150 686 $a D27.888.569.035.035 750 $a Antineoplastic Agents, Alkylating $8 eng 801 -0
$a US $b DNLM $c 19950526 801 -2
$a SK $b BA006 $c 20060315 801 -2
$a SK $b BA006 $c 20091202 980 $x M
Počet záznamov: 1