A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively.
Pozri aj (FX) v slov.
syndróm rezistencie voči hormónom štítnej žľazy
Pozri aj (FX) v angl.
Thyroid Hormone Resistance Syndrome
Odkazy
(20) - ČLÁNKY
(7) - heslo MeSH
(3) - CiBaMed
(2) - KNIHY
predmetové heslo
openseadragon
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