An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
látka antiarytmická látky antifibrilačné depresanty srdcové depresant myokardiálny
Angl. X odkazy
Anti-Arrhythmia Agent Anti-Arrhythmia Drug Anti-Arrhythmic Antiarrhythmia Agent Antiarrhythmia Drug Antiarrhythmic Drug Antifibrillatory Agent Antifibrillatory Agents Cardiac Depressant Cardiac Depressants Myocardial Depressant Myocardial Depressants
Vysvetľujúca pozn. v angl.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.
