A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
CCND1 Protein PRAD1 Protein Proto-Oncogene Proteins c-bcl-1 bcl-1 Proto-Oncogene Proteins c-bcl-1 Proteins
Vysvetľujúca pozn. v angl.
Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.
Pozri aj (FX) v slov.
lymfóm z plášťových buniek
Pozri aj (FX) v angl.
Lymphoma, Mantle-Cell
Odkazy
(9) - ČLÁNKY
(2) - heslo MeSH
(1) - KNIHY
predmetové heslo
openseadragon
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