Alzheimer beta-Protein Amyloid Protein A4 Amyloid beta-Peptide Amyloid beta-Protein beta Amyloid beta-Amyloid Protein
Vysvetľujúca pozn. v angl.
Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
Pozri aj (FX) v slov.
klbká neurofibrilárne difúzne, s kalcifikáciou neurofibrily proteíny neurofilamentové tauopatie
Pozri aj (FX) v angl.
Diffuse Neurofibrillary Tangles with Calcification Neurofibrils Neurofilament Proteins Tauopathies
Odkazy
(5) - ČLÁNKY
(4) - heslo MeSH
(2) - CiBaMed
(1) - KNIHY
predmetové heslo
openseadragon
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