The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
Pozri aj (FX) v slov.
evolúcia molekulová riadená mutagenéza miestne cielená
Genetic engineering or molecular biology techniques that involve DNA REPAIR mechanisms for incorporating site-specific modifications into a cell's genome.
Pozri aj (FX) v slov.
CRISPR/Cas9 CRISPR/Cas systémy mutagenéza miestne cielená
Pozri aj (FX) v angl.
CRISPR-Associated Protein 9 CRISPR-Cas Systems Mutagenesis, Site-Directed
Odkazy
(5) - ČLÁNKY
(3) - heslo MeSH
predmetové heslo
openseadragon
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