A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30)
Farmakologický účinok
farbivá fluorescenčné
Farmakologický účinok
Fluorescent Dyes
Pozri aj (FX) v slov.
ATP-viažuci kazetový transportér, podrodina B, člen 1
Pozri aj (FX) v angl.
ATP Binding Cassette Transporter, Subfamily B, Member 1
Genes for MEMBRANE TRANSPORT PROTEINS that confer resistance to toxic compounds. Several superfamilies of these multidrug export proteins are known and found in both prokaryotes and eukaryotes.
Pozri aj (FX) v slov.
ATP-viažuci kazetový transportér, podrodina B ATP-viažuci kazetový transportér, podrodina B, člen 1 rezistencia lieková mnohopočetná
Pozri aj (FX) v angl.
ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Resistance, Multiple
proteíny spojené s mnohopočetnou liekovou rezistenciou
Heslo anglicky
Multidrug Resistance-Associated Proteins
Odkazy
proteíny spojené s viacnásobnou liekovou rezistenciou proteín spojený s multiliekovou rezistenciou proteín spojený s liekovou multirezistenciou proteíny asociované s viacnásobnou liekovou rezistenciou proteín asociovaný s multiliekovou rezistenciou proteín asociovaný s liekovou multirezistenciou proteíny spojené s mnohonásobnou liekovou rezistenciou proteíny asociované s mnohonásobnou liekovou rezistenciou
Angl. X odkazy
Multidrug Resistance-Associated Protein
Vysvetľujúca pozn. v angl.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.
Pozri aj (FX) v slov.
ATP-viažuci kazetový transportér, podrodina B rezistencia lieková mnohopočetná
Pozri aj (FX) v angl.
ATP Binding Cassette Transporter, Subfamily B Drug Resistance, Multiple
