Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
Oncogene Protein p190(bcr-abl) Oncogene Protein p210(bcr-abl) bcr-abl Fusion Protein bcr-abl Fusion Proteins
Vysvetľujúca pozn. v angl.
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Pozri aj (FX) v slov.
chromozóm Philadelphia
Pozri aj (FX) v angl.
Philadelphia Chromosome
Odkazy
(21) - ČLÁNKY
(3) - heslo MeSH
(3) - CiBaMed
predmetové heslo
openseadragon
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