Počet záznamov: 1
klbká neurofibrilárne
SYS d016874 LBL 00000cx--j2200000---45-- 005 20240119201502.1 100 $a 19920502asloy0103----ba0 152 $b mesh 250 $a klbká neurofibrilárne $x CH $x CL $x DE $x EN $x GE $x IM $x ME $x MI $x PA $x PH $x PS $x RE $x TR $x UL $x VI $8 slo 300 1-
$a 92 $8 eng 300 1-
$a Neurofibrils (1968-1991) $8 eng 330 1-
$a Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease. $8 eng 450 $a splete neurofibrilárne $5 e $8 slo 550 $3 sllk_un_auth*d009454 $Y Neurofibrils $5 B $a neurofibrily 550 $3 sllk_un_auth*d055956 $Y Diffuse Neurofibrillary Tangles with Calcification $5 F $a klbká neurofibrilárne difúzne, s kalcifikáciou 550 $3 sllk_un_auth*d009454 $Y Neurofibrils $5 F $a neurofibrily 550 $3 sllk_un_auth*d016900 $Y Neurofilament Proteins $5 F $a proteíny neurofilamentové 550 $3 sllk_un_auth*d024801 $Y Tauopathies $5 F $a tauopatie 550 $3 sllk_un_auth*d024801 $Y Tauopathies $5 B $a tauopatie 550 $3 sllk_un_auth*d055956 $Y Diffuse Neurofibrillary Tangles with Calcification $5 B $a klbká neurofibrilárne difúzne, s kalcifikáciou 686 $a A08.675.609.520 686 $a A11.284.430.214.190.750.640.520 686 $a A11.671.573.520 750 $a Neurofibrillary Tangles $8 eng 801 -0
$a US $b DNLM $c 19920502 801 -2
$a SK $b BA006 $c 20070706 801 -2
$a SK $b BA006 $c 20171221 801 -2
$a SK $b BA006 $c 20210910 980 $x M
Počet záznamov: 1