NLR rodina, pyrínovú doménu obsahujúci proteín 3 proteín 1 asociovaný s familiárnym chladovým autoinflamačným syndrómom proteín 1 spojený s familiárnym chladovým autoinflamačným syndrómom NACHT, LRR and PYD domény obsahujúci proteín 3
Scope note in English
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
See also reference (FX) in Slovak
syndrómy asociované s kryopyrínom, periodické inflamazómy
