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proteín protoonkogénový N-Myc
Subject h. proteín protoonkogénový N-Myc Subject h. N-Myc Proto-Oncogene Protein Entry terms BHLHE37 proteín
MYCN proteín
N-Myc proteín
NMYC proteínScope note in English A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer. 
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