Pathological deposition of calcium in the skin and subcutaneous tissue. Excessive calcification of the skin may be associated with underlying diseases that cause tissue damage (e.g., EHLERS-DANLOSÂ SYNDROME; PSEUDOXANTHOMA ELASTICUM; ROTHMUND-THOMSON SYNDROME; and WERNER SYNDROME) or that cause abnormal calcium and phosphate metabolism (e.g., CALCIPHYLAXIS; CHRONICÂ KIDNEYÂ FAILURE; HYPERPARATHYROIDISM; and SARCOIDOSIS).
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