An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Pharmacology effect
antineoplastiká fytogénne inhibítory topoizomerázy I
Pharmacology effect
Antineoplastic Agents, Phytogenic Topoisomerase I Inhibitors
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