Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Pharmacology effect
neurotoxíny
Pharmacology effect
Neurotoxins
See also reference (FX) in Slovak
antitoxín tetanický
See also reference (FX) in English
Tetanus Antitoxin
Links
(2) - MeSH descriptor
subject heading
openseadragon
Number of the records: 1
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