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Lambertov-Eatonov myastenický syndróm

  1. Subject h.Lambertov-Eatonov myastenický syndróm
    Subject h.Lambert-Eaton Myasthenic Syndrome
    Entry termssyndróm myastenický
    Eatonov-Lambertov syndróm
    English X referencesEaton-Lambert Syndrome
    Myasthenic Syndrome, Lambert-Eaton
    Scope note in EnglishAn autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
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