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NADPH-oxidázy

  1. Subject h.NADPH-oxidázy
    Subject h.NADPH Oxidases
    Entry termsNADPH oxidáza
    NAD(P)H oxidázy
    NAD(P)H oxidáza
    proteíny NOX
    English X referencesNADPH Oxidase
    Scope note in EnglishA family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
    See also reference (FX) in Slovak choroba granulomatózna chronická
    See also reference (FX) in English Granulomatous Disease, Chronic
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