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detoxikácia metabolická, fáza I

  1. Subject h.detoxikácia metabolická, fáza I
    Subject h.Metabolic Detoxication, Phase I
    Entry termsdetoxikácia metabolická oxidatívna
    detoxikácia, fáza I
    fáza I metabolickej detoxikácie
    Scope note in EnglishFunctionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
    See also reference (FX) in Slovak interakcie liekové
    See also reference (FX) in English Drug Interactions
    Links (1) - MeSH descriptor
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