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receptory pre-B-buniek

Subject h.	receptory pre-B-buniek
Subject h.	Pre-B Cell Receptors
Entry terms	receptory pre-B buniek
Scope note in English	Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.
Links	(3) - ARTICLES
	(1) - CiBaMed

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Number of the records: 1