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proteíny neurofilamentové

  1. Record numberd016900
    Date06.06.2025
    TypeM
    Topical termproteíny neurofilamentové
    Other termEnglish (Pseudonym) Neurofilament Protein
    Slovak (Pseudonym) proteín neurofilamentov
    Slovak (Pseudonym) proteín neurofilamentový
    Slovak (Pseudonym) proteíny neurofilamentov
    Slovak (Pseudonym) proteín ťažkých reťazcov neurofilamentov
    Slovak (Pseudonym) proteíny neurofilamentové tripletové
    See also(Later heading) Alzheimerova choroba
    (Later heading) klbká neurofibrilárne
    UDCD05.750.078.593.630D12.776.220.475.630D12.776.631.630
    NoteType III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
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