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hydrolázy Nudix
Heslo hydrolázy Nudix Heslo anglicky Nudix Hydrolases Odkazy Nudix hydrolázy
Nudix hydroláza
hydrolázy nukleoziddifosfátov viazaných na x (akúkoľvek časť)
hydrolázy nukleoziddifosfátov viazaných na x (akýkoľvek zvyšok)
Nudix proteínyAngl. X odkazy Nucleoside Diphosphates-Linked to Moiety-X Hydrolases
Nudix Hydrolase
Nudix ProteinsVysvetľujúca pozn. v angl. A group of Mg2+/Mn2+-dependent mainly pyrophosphohydrolases that hydrolyzes structures of NUcleoside DIphosphate linked to another moiety X to nucleoside monophosphate and X-Phosphate. Nudix hydrolases share conserved Nudix box (GX5EX7REUXEEXGU) and degrade variety of substrates including oxidized nucleotides (e.g., MutT) and metabolic intermediates (e.g., THIAMINE PYROPHOSPHATASE). In humans, Nudix superfamily proteins such as MutT proteins participate in DNA damage repairs. Mutations on a nudix hydrolase (NUDT15) are associated with a PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS disorder called THPM2, and mutations in nudix hydrolase (NUDT2) are associated with IDDPN, a developmental intellectual disorder. 
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Počet záznamov: 1